Wen-Chi ChangProfessor

1. Bioinformatics databases and software development

2. Applied bioinformatics research and biological big data analysis

• Investigation of gene transcriptional regulation mechanisms and construction of regulatory networks (with emphasis on promoter sequences, transcription factors, and histone modifications in gene expression control)
• Study of non-coding RNAs in gene expression regulation
• Research on interactions between soil microbiomes and plants

• PlantPAN: A comprehensive plant TF-TFBS database for analyzing gene regulatory networks, providing regulatory factor information and enabling cross-species comparative analysis.
• EXPath/EXPath Tool: A tool for rapidly identifying differentially expressed genes from high-throughput gene expression data (e.g., microarrays and next-generation sequencing) and analyzing gene functions and associated metabolic pathways.
• Soil microbiome metagenomic analysis: In collaboration with agricultural experiment stations, we use next-generation sequencing to investigate the effects of long-term organic and conventional farming on crop yield, disease resistance, and soil sustainability.
• sRIS: A system integrating transcriptome, small RNA sequencing, degradome sequencing, and viral genome data to study regulatory interactions among plant genes, microRNAs, and viral small interfering RNAs (vsiRNAs).
• microRPM: A machine-learning-based microRNA prediction system that identifies known and novel microRNAs directly from small RNA sequencing data.