Prof. Liaw, Hungjiun
TEL:+886-6-275-7575 ext.58127 研究室:58104 or 58114轉22
Research interests：Chromosome damage repair mechanism、Cancer Genomics、Yeast Genetics.
The major interest of my laboratory is DNA damage response (DDR) in eukaryotic cells. We specifically focus on the DNA damage tolerance pathways and chromatin modification and remodeling in the maintenance of genome integrity. We have used the genetic, biochemical, and molecular approaches to elucidate the mechanism underlying genomic instability.
|Ph.D. Degree||Biochemistry, Tulane University, USA|
|2016 Associate Professor||Department of Life Sciences, National Cheng Kung University|
|2010 Assistant Professor||Department of Life Sciences, National Cheng Kung University|
|2006 Postdoc fellow||National Human Genome Research Institute, NIH, USA|
Awards and Honors
- Su WP, Ho YC, Wu CK, Hsu SH, Shiu JL, Huang JC, Chang SB, Chiu WT, Hung JJ, Liu TL, Wu WS, Wu PY, Su WC, Chang JY, Liaw HJ*. (2017) Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways. Scientific Reports 7: 3879.
- Su WP, Hsu SH, Chia LC, Lin JY, Chang SB, Jiang ZD, Lin YJ, Shih MY, Chen YC, Chang MS, Yang WB, Hung JJ, Hung PC, Wu WS, Myung KJ, Liaw HJ*. (2016) Combined interactions of plant homeodomain and chromodomain regulate NuA4 activity at DNA double-strand breaks. Genetics. 202, 77-92.
- Su WP, Hsu SH, Wu CK, Chang SB, Lin YJ, Yang WB, Hung JJ, Chiu WT, Tzeng SF, Chang JY, Su WC, Liaw HJ*. (2014) Chronic low-dose cisplatin treatment induces replication dependent sister chromatid recombination to confer cisplatin resistant phenotype in nasopharyngeal carcinoma. Oncotarget. 5: 6323-37.
- Motegi A#, Liaw HJ#, Lee KY, Roest HP, Maas A, Wu X, Moinova H, Markowitz SD, Hao Ding, Hoeijmakers JHJ, and Myung KJ. (2008) Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc. Natl. Acad. Sci. USA. 105(34): 12411-6. (# equal contribution)