Prof. Liaw, Hungjiun

 Professor
Prof. Liaw, Hungjiun
 
中文
TEL:+886-6-275-7575 ext.58127    研究室:58104 or 58114轉22
Email: liawh@mail.ncku.edu.tw

Research interests：Chromosome damage repair mechanism、Cancer Genomics、Yeast Genetics.
Introduction of Laboratory：

The major interest of my laboratory is DNA damage response (DDR) in eukaryotic cells. We specifically focus on the DNA damage tolerance pathways and chromatin modification and remodeling in the maintenance of genome integrity. We have used the genetic, biochemical, and molecular approaches to elucidate the mechanism underlying genomic instability.

Education

Ph.D.  Degree Biochemistry, Tulane University, USA
M.S. Degree Biochemical Sciences, National Taiwan University
B.S  Degree Chemistry, National Taiwan University

Experience

2023 Professor Department of Life Sciences, National Cheng Kung University
2016  Associate Professor Department of Life Sciences, National Cheng Kung University
2010  Assistant Professor Department of Life Sciences, National Cheng Kung University
2006  Postdoc fellow National Human Genome Research Institute, NIH, USA

Awards and Honors

 

 

Publications

Periodical articles (Link)

  1. Cheng-Kuei Wu, Jia-Lin Shiu, Chao-Liang Wu, Chi-Feng Hung, Yen-Chih Ho, Yen-Tzu Chen, Sheng-Yung Tung, Cheng-Fa Yeh, Che-Hung Shen, Hungjiun Liaw*, Wen-Pin Su*. (2024, Mar). APLF facilitates interstrand DNA crosslink repair and replication fork protection to confer cisplatin resistance. Nucleic Acids Res. 52(10):5676-5697. (*corresponding authors)

  2. Chia-Lun Guh, Kai-Hang Lei, Yi-An Chen, Yi-Zhen Jiang, Hao-Yen Chang, Hungjiun Liaw, Hung-Wen Li, Hsin-Yung Yen, Peter Chi. (2023, Nov). RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases. Nucleic Acids Res. 51(21):11717-11731.

  3. Yen-Chih Ho, Chen-Syun Ku, Siang-Sheng Tsai, Jia-Lin Shiu, Yi-Zhen Jiang, Hui Emmanuela Miriam, Han-Wen Zhang, Yen-Tzu Chen, Wen-Tai Chiu, Song-Bin Chang, Che-Hung Shen, Kyungjae Myung, Peter Chi, Hungjiun Liaw* (2022). PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair. PLoS Genet. 18: e1010545. (* corresponding author)

  4. Cheng-Kuei Wu, Man-Ting Wei, Hung-Chang Wu, Cheng-Lin Wu, Cheng-Ju Wu, Hungjiun Liaw*, Wen-Pin Su*. (2022, Sep). BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation. Scientific Reports, 12(1),16310. (* corresponding authors)

  5. Jia-Lin Shiu, Cheng-Kuei Wu, Song-Bin Chang, Yan-Jhih Sun, Yen-Ju Chen, Chien-Chen Lai, Wen-Tai Chiu, Wen-Tsan Chang, Kyungjae Myung, Wen-Pin Su, Hungjiun Liaw* (2020). The HLTF-PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate. Oncogenesis 9(12):104. (* corresponding author)

  6. Wen-Pin Su, Sen-Huei Hsu, Li-Chiao Chia, Jui-Yang Lin, Song-Bin Chang, Zong-da Jiang, Yi-Ju Lin, Min-Yu Shih, Yi-Cheng Chen, Mau-Sun Chang, Wen-Bin Yang, Jan-Jong Hung, Po-Cheng Hung, Wei-Sheng Wu, Kyungjae Myung, Hungjiun Liaw *. (2016) Combined interactions of plant homeodomain and chromodomain regulate NuA4 activity at DNA double-strand breaks. Genetics. 202, 77-92. (* corresponding author)