Prof. Peng, I-Chen

Assistant Professor
Prof. Peng, I-Chen
 

中文
TEL:+886-6-275-7575 ext.58123    研究室:58104 or 58114轉61
Email: ipeng@mail.ncku.edu.tw
Web:Laboratory Website
Research interests:
Molecular medicine, nutrition and epigenetics, cancer metabolism

COLLABORATIONS:
Dr. Peng’s research focuses on targeting lipid and glutamine metabolism to treat obesity and obesity-related diseases, particularly the molecular mechanisms of oncogenic signaling and epigenetic regulation of lipogenesis and glutamine metabolism in adipocytes, hepatocytes and cancer cells.

Research Summary:
Alteration of lipid metabolism has been increasingly recognized as a hallmark of obesity andobesity-related diseases, i.e. cancer. Oncogenic growth signaling upregulates glycolysis, lipogenesis and glutamine metabolism to meet the biosynthetic demands of rapidly proliferating tumor cells. However, how cancer cells manipulate glucose, lipid and glutamine metabolism is unclear. The metabolic sensor AMPK is stimulated upon fasting, exercise and calorie restriction to augment lipid and glucose metabolism. Oncogenic Myc has been shown to favor the conversion of glucose to lactate and increase the usage of glutamine in cancer cells. Given that metabolic reprogramming is modulated by circadian-, nutritional-, and environmental-driven molecular signals, epigenetic alterations of metabolic gene expression are dynamic and reversible. Recently, we have discovered that Myc functions as an epigenetic regulator to increase the expression of glutamine synthetase. Therefore, we are interested in investigating mechanotransduction (i.e., AMPK and Myc signaling), transcriptional and epigenetic regulation of lipogenesis and glutamine metabolismin in adipocytes, hepatocytes and cancer cells. Our long term goal is to determine the key enzymes for targeting in cancer metabolism and translation to the clinic.

Active research projects include:

  1. Study of the molecular link between AMPK and Myc signaling with cancer metabolism.
  2. Investigation of epigenetic regulation of lipogenesis and glutamine metabolism in adipocytes, hepatocytes and cancer cells.

Education

Ph.D. Degree Graduate Program in Biochemistry and Molecular Biology, University of California, Riverside, CA, USA
Master Degree Graduate Institute of Agricultural Chemistry, Microbiology Division, National Taiwan University, Taiwan
Bachelor’s Degree Department of Agricultural Chemistry, National Taiwan University, Taiwan

Experience

2014 Assistant Professor Department of Life Sciences, National Cheng Kung University, Taiwan
2012 Postdoctoral Fellow Department of Molecular Genetics and Microbiology, Stony Brook University, NY, USA
2011 Postdoctoral Fellow Division of Biomedical Sciences, University of California, Riverside, CA, USA

Awards and Honors

 

 

Publications

Periodical articles (Link)

Conference paper

  1. I-Chen Peng. “Myc induces expression of glutamine synthetase through promoter demethylation.” The 5th International Conference and Exihibition on Metabolomics 2016, Osaka, Japan. (Invited Speaker)
  2. I-Chen Peng, Alex J. Bott, Yongjun Fan, Brandon Faubert, Lu Zhao, Jinyu Li, Sarah Neidler, Yu Sun, Nadia Jaber, Dawid Krokud, Maria Hatzoglou, Scott Powers, Daniel J. Murphy, Russell Jones, Song Wu, Geoffrey Girnun, and Wei-Xing Zong. “Myc induces expression of glutamine synthetase through thymine DNA glycosylase-mediated promoter demethylation.” The 15th SCBA International Symposium 2015, Academia Sinica, Taipei, Taiwan.
  3. I-Chen Peng, Alex J. Bott, Yongjun Fan, Brandon Faubert, Lu Zhao, Jinyu Li, Sarah Neidler, Yu Sun, Nadia Jaber, Dawid Krokud, Maria Hatzoglou, Scott Powers, Daniel J. Murphy, Russell Jones, Song Wu, Geoffrey Girnun, and Wei-Xing Zong. “Myc induces expression of glutamine synthetase through thymine DNA glycosylase-mediated promoter demethylation.”The 8th France-Taiwan Frontiers of Science 2015, Kaohsiung, Taiwan
  4. I-Chen Peng, Alex Bott, Yongjun Fan, Nadia Jaber, and Wei-Xing Zong. “c-Myc Induces Expression of Glutamine Synthetase through DNA demethylation.” Gloria and Mark Snyder Symposium for Cancer Medicine 2014, Stony Brook, New York, USA.
  5. I-Chen Peng, Alex Bott, Yongjun Fan, Nadia Jaber, and Wei-Xing Zong. “c-Myc Induces Expression of Glutamine Synthetase through DNA demethylation.” Molecular Genetics and Microbiology Annual Department Retreat 2013, Port Jefferson, New York, USA.
  6. I-Chen Peng, Zhen Chen, Pang-Hung Hsu, Mei-I Su, Ming-Daw Tsai, and John Y-J. Shyy. “Glucagon Activates the AMP-Activated Protein Kinase/Acetyl-CoA Carboxylase Pathway in Adipocytes.” Experimental Biology Meeting 2010, Anaheim, California, USA.
  7. I-Chen Peng and John Y-J. Shyy. “AMP-Activated Protein Kinase Phosphorylates Acetyl-CoA Carboxylase at Ser-79 Responding to Glucagon.” 21st Annual Biochemistry and Molecular Biology Research Symposium 2009, Riverside, California, USA.
  8. Zhen Chen, I-Chen Peng, Wei Sun, Mei-I Su, Pang-Hung Hsu, Songqin Pan, Ming-Daw Tsai, and John Y-J. Shyy. “Shear Stress Increases the Phosphorylation of eNOS Ser-633 and Level of Sirt1.” The 12th SCBA International Symposium 2009, Academia Sinica, Taipei, Taiwan.