廖泓鈞 教授

教授
廖泓鈞

English
電話:+886-6-275-7575 ext. 58127    研究室:58104 or 58114轉22
email: liawh@mail.ncku.edu.tw

研究專長:DNA 複製,修復,與重組,癌症與基因體不穩定機制。
研究方向:
  

癌症細胞具有基因體不穩定(Genomic instability)的特性,像是染色體數目非23對(aneuploidy),以及染色體重組(gross chromosomal rearrangement)的現象。其中基因體不穩定的現象常常是由於DNA複製(replication),修復(repair),與重組(recombination)機制的失調而造成的,因為這些機制的失調,而導致細胞會面臨不斷的複製壓力(replication stress),而造成染色體斷裂與重組。這些相關的調控基因的突變也常被發現在癌細胞中。像是同源重組(homologous recombination)基因BRCA1與BRCA2與范可尼(Fanconi Anemia)修復路徑基因的突變會導致基因體不穩定與癌症的生成息息相關。因此我的研究主要在探討DNA複製,修復,與重組相關的基因,其基因突變對複製壓力,造成基因體不穩定的分子機制。

        我的實驗室已經開發許多研究複製壓力,重組,基因體不穩定的工具,包含DNA fiber, DNA combing, metaphase spreads, sister chromatid exchange, homologous recombination assay,iPOND以及SIRF。利用這些工具,我們可以研究基因突變對DNA複製的影響,包含replication speed,fork density,stalled forks, new origin firing, ssDNA replication gaps,染色體斷裂,重組,以及蛋白結合到複製叉的情形。這些平台也提供給國內外學者使用。

學歷

博士  Biochemistry, Tulane University, USA
碩士 生化科學研究所,國立台灣大學
學士 化學系,國立台灣大學

經歷

年份 職位 機構
2023 教授 國立成功大學 生命科學系
2016 副教授 國立成功大學 生命科學系
2010 助理教授 國立成功大學 生命科學系
2006 Postdoc fellow National Human Genome Research Institute, NIH, USA

代表著作

  1. Cheng-Kuei Wu, Jia-Lin Shiu, Chao-Liang Wu, Chi-Feng Hung, Yen-Chih Ho, Yen-Tzu Chen, Sheng-Yung Tung, Cheng-Fa Yeh, Che-Hung Shen, Hungjiun Liaw*, Wen-Pin Su*. (2024, Mar). APLF facilitates interstrand DNA crosslink repair and replication fork protection to confer cisplatin resistance. Nucleic Acids Res. 52(10):5676-5697. (*corresponding authors)

  2. Chia-Lun Guh, Kai-Hang Lei, Yi-An Chen, Yi-Zhen Jiang, Hao-Yen Chang, Hungjiun Liaw, Hung-Wen Li, Hsin-Yung Yen, Peter Chi. (2023, Nov). RAD51 paralogs synergize with RAD51 to protect reversed forks from cellular nucleases. Nucleic Acids Res. 51(21):11717-11731.

  3. Yen-Chih Ho, Chen-Syun Ku, Siang-Sheng Tsai, Jia-Lin Shiu, Yi-Zhen Jiang, Hui Emmanuela Miriam, Han-Wen Zhang, Yen-Tzu Chen, Wen-Tai Chiu, Song-Bin Chang, Che-Hung Shen, Kyungjae Myung, Peter Chi, Hungjiun Liaw* (2022). PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair. PLoS Genet. 18: e1010545. (* corresponding author)

  4. Cheng-Kuei Wu, Man-Ting Wei, Hung-Chang Wu, Cheng-Lin Wu, Cheng-Ju Wu, Hungjiun Liaw*, Wen-Pin Su*. (2022, Sep). BMP2 promotes lung adenocarcinoma metastasis through BMP receptor 2-mediated SMAD1/5 activation. Scientific Reports, 12(1),16310. (* corresponding authors)

  5. Jia-Lin Shiu, Cheng-Kuei Wu, Song-Bin Chang, Yan-Jhih Sun, Yen-Ju Chen, Chien-Chen Lai, Wen-Tai Chiu, Wen-Tsan Chang, Kyungjae Myung, Wen-Pin Su, Hungjiun Liaw* (2020). The HLTF-PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate. Oncogenesis 9(12):104. (* corresponding author)

  6. Wen-Pin Su, Sen-Huei Hsu, Li-Chiao Chia, Jui-Yang Lin, Song-Bin Chang, Zong-da Jiang, Yi-Ju Lin, Min-Yu Shih, Yi-Cheng Chen, Mau-Sun Chang, Wen-Bin Yang, Jan-Jong Hung, Po-Cheng Hung, Wei-Sheng Wu, Kyungjae Myung, Hungjiun Liaw *. (2016) Combined interactions of plant homeodomain and chromodomain regulate NuA4 activity at DNA double-strand breaks. Genetics. 202, 77-92. (* corresponding author)

全部論文著作連結