張素瓊 名譽教授

學歷

經歷

榮譽與獎勵

論文著作

近五年代表著作

1. 1. Yu-Chi Chen, Hung-Yu Lin, Sue-Joan Chang, Ching-Yu Huang and Yun-Ching Chang*. Oligonol, an oligomerized polyphenol from Lichi chinese extract, enhances cisplatin sensitivity and inhibits invasion in bladder cancer cells by the TNF-α/NF-κB/Snail pathway. CyTA-Journal of Food,23:1, 2461658. https://doi.org/10.1080/19476337.2025.2461658 (SCI, IF= 2.7)
   2. Yun-Ching Chang,Yu-Yan Lan , Hung-Yu Lin,Cheng Liu and Sue-Joan Chang*.

      Low-molecular-weight polyphenol promotes cell sensitivity to cisplatin and alleviates cancer-related muscle atrophy via NF-κB suppression in oral squamous cell carcinoma. J Oral Biosciences 67(2025)100595. https://doi.org/10.1016/j.job.2024.100595 (SCI, IF= 2.83)

   3. Yun-Ching Chang, Yu-Chi Chen, Yin-Ching Chan, Cheng Liu and Sue-Joan Chang*. Oligonol®, an Oligomerized Polyphenol from Litchi Chinensis, Enhances Branched-Chain Amino Acid Transportation and Catabolism to Alleviate Sarcopenia. J. Mol. Sci. 2024, 25, 11549. https://doi.org/10.3390/ijms252111549 (SCI, IF= 5.6, Q1 in “Biochemistry & Molecular Biology”
   4. Yung‑Chia Chen, Yin‑Ching Chan, Yun‑Ching Chang, Hung‑Wen Liu, Chung‑Che Cheng and Sue-Joan Chang*. Mitigation of high‑fat diet‑induced sarcopenia by Toona sinensis fruit extracts via autophagic flux and mitochondrial quality control. Food Science and Biotechnology. 2024 June 9. https://doi.org/10.1007/s10068-024-01610-3 (SCI, IF= 3.2, Q1 in“food science and technology”)
   5. Hung-Wen Liu and Sue-Joan Chang*. Effects of Green Tea–Derived Natural Products on Resistance Exercise Training in Sarcopenia: A Retrospective Narrative Mini-Review. J Food Drug Anal. 2023. August 31; 31(3) : 381-386 (SCI, IF= 6.157 in 2022-2023)
   6. Shui-Yuan Feng , Shu-Jing Wu , Yun-Ching Chang , Lean-Teik Ng and Sue-Joan Chang* .Stimulation of GLUT4 Glucose Uptake by Anthocyanin-Rich Extract from Black Rice (Oryza sativa L.) via PI3K/Akt and AMPK/p38 MAPK Signaling in C2C12 Cells.Metabolites.2022, 12(9),856; doi:10.3390/metabo12090856.
   7. Li-Ning Peng^*, Ming-Hsien Lin , Huei-Fang Lee, Chia-Chia Hsu, Sue-Joan Chang, Liang-Kung Chen. Clinical efficacy of Oligonol ® supplementation on metabolism and muscle health in middle-aged and older adults: A double-blinded randomized controlled trial. Arch Gerontol Geriatr. 2022. Jul 31; 103:104784.doi: 10.1016/j.archger.2022.104784 (SCI, IF= 4.163)
   8. Sue-Joan Chang *, Yin-Ching Chan, Hung-Wen Liu, Yun-Chin Chang and Shu-Jing Wu. Diet and health: functions and molecular mechanism. Proceeding of Canada –Taiwan bilateral conference on nutrition, health benefit and innovative processing of whole grains and pulses. 2022. P.20-32.
   9. Yun-Ching Chang, Yin-Chin Chan, Shu-Hui Hu, Ming-Yi Liu, Sue-Joan Chang*. The green tea polyphenol epigallocatechin-3-gallate attenuates age-associated muscle loss via regulation of myostatin and miR-486.Arch of Biochem and Biophy.2020 doi: https://doi.org/10.1016/j.abb.2020.108511. (SCI) ( IF: 4.013)
   10. Hung-Wen Liu, Yun-Ching Chang, Yin-Ching Chan, Shu-Hui Hu, Ming-Yi Liu, Sue-Joan Chang*. Dysregulations of mitochondrial quality control and autophagic flux at an early age lead to progression of sarcopenia in SAMP8 mice. Biogerontology. 2020 21(3):367-380. DOI:10.1007/s10522-020-09867-x (SCI) ( IF: 4.277)

   11. Yin-Ching Chan, Ci-Sian Wu, Tsai-Chen Wu, Yu-Hsuan Lin and Sue-Joan Chang *. A Standardized Extract of Asparagus officinalis Stem (ETAS^®) Ameliorates Cognitive Impairment, Inhibits Amyloid β Deposition via BACE-1 and Normalizes Circadian Rhythm Signaling via MT1 and MT2. Nutrients. 2019 Jul 17;11(7). pii: E1631. doi: 10.3390/nu11071631.

   12. Chang YC, Chen YT, Liu HW, Chen YA, Chen YJ and Chang SJ*.Oligonol Alleviates Sarcopenia by Regulation of Signaling Pathways Involved in Protein Turnover and Mitochondrial Quality.Mol Nutr Food Res.2019 Feb. doi: 10.1002/mnfr.201801102.

   13. Chang YC, Liu HW, Chen YT, Chen YA, Chen YJ and Chang SJ*. Resveratrol protects muscle cells against palmitate-induced cellular senescence and insulin resistance through ameliorating autophagic flux. J Food Drug Anal. 2018 Jul;26(3):1066-1074.
   14. Liu HW and Chang SJ. Moderate Exercise Suppresses NF-κB Signaling and Activates the SIRT1-AMPK-PGC1α Axis to Attenuate Muscle Loss in Diabetic db/db Mice. Front Physiol. 2018 May 29;9:636.
   15. Liu HW, Chen YJ, Chang YC and Chang SJ*. Oligonol, a Low-Molecular Weight Polyphenol Derived from Lychee, Alleviates Muscle Loss in Diabetes by Suppressing Atrogin-1 and MuRF1. Nutrients. 2017 Sep 20;9(9). pii: E1040.
   16. Liu HW, Chan YC, Wei CC, Chen YA, Wang MF and Chang SJ*. An alternative model for studying age-associated metabolic complications: Senescence-accelerated mouse prone 8. Exp Gerontol. 2017 Aug 23. 99:61-68.
   17. Hu SH, Chen KS, Liu MY, Cheung CK, Wang JC and Chang SJ*. Optimization of Submerged Cultivation Conditions for Production of Big Cup Culinary-Medicinal Mushroom Clitocybe maxima (Agaricomycetes) Biomass with Significant Antioxidative and Antihyperlipidemic activities. Int J Med Mushrooms. 2017;19(7):641-651.
   18. Chen YF, Shiau AL, Chang SJ, Fan NS, Wang CT, Wu CL and Jan JS. One-dimensional poly(L-lysine)-block-poly(L-threonine) assemblies exhibit potent anticancer activity by enhancing membranolysis. Acta Biomater. 2017 Jun;55:283-295.
   19. Liu HW, Wei CC, Chen YJ, Chen YA and Chang SJ*. Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle. Mol Nutr Food Res. 2016,60:2288-2296.
   20. Liu HW, Wei CC and Chang SJ*. Low-molecular-weight Polyphenols Protect Kidney Damage through Suppressing NF-B and Modulating Mitochondrial Biogenesis in Diabetic db/db Mice. Food & Function. 2016; 7. 1941-9.
   21. Liu HW, Chan YC, Wang MF, Wei CC and Chang SJ*. Dietary (-)-epigallocatechin-3-gallate supplementation counteracts aging-associated skeletal muscle insulin resistance and fatty liver in senescence-accelerated mouse. J Agric Food Chem. 2015 Sep 30;63(38):8407-17.
   22. Liu HW, Huang WC, Yu WJ and Chang SJ*. Toona Sinensis ameliorates insulin resistance via AMPK and PPARγ pathways. Food Funct. 2015 Jun;6(6):1855-64.
   23. Liu HW, Tsai YT and Chang SJ*. Toona sinensis leaf extract inhibits lipid accumulation through up-regulation of genes involved in lipolysis and fatty acid oxidation in adipocytes. J Agric Food Chem. 2014 Jun 25;62(25):5887-96.

近三年國際會議

1.     Oligonol^® promotes chemosensitivity to cisplatin and prevents cisplatin-induced muscle wasting via NFκB suppression. International Congress on Nutrition and Integrative Medicine. （The 31^st ICNIM2023）「第三十一屆統合醫療機能性食品國際會議」, Sapporo, Japan. 2023.07.08-09 (Invited speaker)

2.     International exchange Meeting(The 6^th IEM2023) 「第六屆國際交流會議」, Sapporo, Japan. 2023.07.07 (Invited scholar)

3.     Non-proteinogenic amino acids in sarcopenia第22屆國際營養大會(IUNS-ICN 22nd International Congress of Nutrition). Tokyo, Japan. 2022.12.06- 11.(Invited speaker)

4.      2019「第七屆食品因子(ICoFF)、第十二屆營養保健品與機能性食品(ISNFF)及第九屆多酚類與健康(ICPH)聯合國際會議」(7th International Conference on Food Factors, the 12th International Conference and Exhibition on Nutraceuticals and Functional Foods and the 9th International Conference on Polyphenols and Health)。講題: 「Food Factors for Skeletal Muscle Health (有益於骨骼肌健康的食品因子)」、擔任座長並任大會國際指導委員。2019.11.28-12.05 日本神戶

5.      2019 5th Asian Conference for Frailty and Sarcopenia (5ACFS),第五屆亞洲衰弱與肌少症國際會議，講題: 「肌少症的治療標的:粒腺體品質與微環境」2018 12. 22-24. 台北

6.     2019第二十七屆統合醫療機能性食品國際會議(The 27th International Congress on Nutrition and Integrative Medicine, ICNIM 2019) ， 講題: 「 Oligonol^®透過調控肌肉蛋白質轉換與粒腺體品質可減緩肌少症」2019.7.25-27. 日本北海道

7.      2018 APNNO 泛亞洲營養基因體學國際研討會 (Asia-Pacific Nutrigenomics & nutrigenetics Organization) 講題:「肌少症的治療標的」。2018.12.2-5.日本東京

全部論文著作連結

專利

技術轉移